解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Drosophila melanogaster females show changes in behavior and physiology after mating that are thought to maximize the number of progeny resulting from the most recent copulation. Sperm and seminal fluid proteins induce post-mating changes in females, however, very little is known about the resulting gene exp...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-541
更新日期:2010-10-06 00:00:00
abstract:BACKGROUND:miRNAs are small, non-coding RNA molecules that mainly act as negative regulators of target gene messages. Due to their regulatory functions, they have lately been implicated in several diseases, including malignancies. Roughly half of known miRNA genes are located within previously annotated protein-coding ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-533
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Accurate identification of synteny blocks is an important step in comparative genomics towards the understanding of genome architecture and expression. Most computer programs developed in the last decade for identifying synteny blocks have limitations. To address these limitations, we recently developed a ro...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-516
更新日期:2010-09-24 00:00:00
abstract:BACKGROUND:Bacterial phenotype may be profoundly affected by the physical arrangement of their genes in the genome. The Gram-negative species Aggregatibacter actinomycetemcomitans is a major etiologic agent of human periodontitis. Individual clonal types of A. actinomycetemcomitans may exhibit variable virulence and di...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-489
更新日期:2010-09-08 00:00:00
abstract:BACKGROUND:Bacterial vaginosis (BV) is an ecological disorder of the vaginal microbiota that affects millions of women annually, and is associated with numerous adverse health outcomes including pre-term birth and the acquisition of sexually transmitted infections. However, little is known about the overall structure a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-488
更新日期:2010-09-07 00:00:00
abstract:BACKGROUND:The relationships between parasitoids and their insect hosts have attracted attention at two levels. First, the basic biology of host-parasitoid interactions is of fundamental interest. Second, parasitoids are widely used as biological control agents in sustainable agricultural programs. Females of the grega...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-484
更新日期:2010-09-02 00:00:00
abstract:BACKGROUND:Calcium ion is tightly regulated in body fluids and for euryhaline fish, which are exposed to rapid changes in environmental [Ca2+], homeostasis is especially challenging. The gill is the main organ of active calcium uptake and therefore plays a crucial role in the maintenance of calcium ion homeostasis. To ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-476
更新日期:2010-08-17 00:00:00
abstract:BACKGROUND:Single Nucleotide Polymorphisms (SNPs) can be used as genetic markers for applications such as genetic diversity studies or genetic mapping. New technologies now allow genotyping hundreds to thousands of SNPs in a single reaction.In order to evaluate the potential of these technologies in pea, we selected a ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-468
更新日期:2010-08-11 00:00:00
abstract:BACKGROUND:With the advance of new massively parallel genotyping technologies, quantitative trait loci (QTL) fine mapping and map-based cloning become more achievable in identifying genes for important and complex traits. Development of high-density genetic markers in the QTL regions of specific mapping populations is ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-469
更新日期:2010-08-11 00:00:00
abstract:BACKGROUND:Systems biology and functional genomics require genome-wide datasets and resources. Complete sets of cloned open reading frames (ORFs) have been made for about a dozen bacterial species and allow researchers to express and study complete proteomes in a high-throughput fashion. RESULTS:We have constructed an...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-470
更新日期:2010-08-11 00:00:00
abstract:BACKGROUND:To date, oil-rich plants are the main source of biodiesel products. Because concerns have been voiced about the impact of oil-crop cultivation on the price of food commodities, the interest in oil plants not used for food production and amenable to cultivation on non-agricultural land has soared. As a non-fo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-462
更新日期:2010-08-06 00:00:00
abstract:BACKGROUND:Bacterial genomes possess varying GC content (total guanines (Gs) and cytosines (Cs) per total of the four bases within the genome) but within a given genome, GC content can vary locally along the chromosome, with some regions significantly more or less GC rich than on average. We have examined how the GC co...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-464
更新日期:2010-08-06 00:00:00
abstract:BACKGROUND:Shotgun sequencing of environmental DNA is an essential technique for characterizing uncultivated microbes in situ. However, the taxonomic and functional assignment of the obtained sequence fragments remains a pressing problem. RESULTS:Existing algorithms are largely optimized for speed and coverage; in con...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-461
更新日期:2010-08-05 00:00:00
abstract:BACKGROUND:Human leukocyte antigen (HLA)-B27 is strongly associated with the development of reactive arthritis (ReA) in humans after salmonellosis. Human monocytic U937 cells transfected with HLA-B27 are less able to eliminate intracellular Salmonella enterica serovar Enteritidis than those transfected with control HLA...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-456
更新日期:2010-07-30 00:00:00
abstract:BACKGROUND:Species of the crenarchaeon Sulfolobus harbour three replication origins in their single circular chromosome that are synchronously initiated during replication. RESULTS:We demonstrate that global gene expression in two Sulfolobus species is highly biased, such that early replicating genome regions are more...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-454
更新日期:2010-07-28 00:00:00
abstract:BACKGROUND:Lychas mucronatus is one scorpion species widely distributed in Southeast Asia and southern China. Anything is hardly known about its venom components, despite the fact that it can often cause human accidents. In this work, we performed a venomous gland transcriptome analysis by constructing and screening th...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-452
更新日期:2010-07-28 00:00:00
abstract:BACKGROUND:Brown and white adipose tissues (BAT and WAT) play critical roles in controlling energy homeostasis and in the development of obesity and diabetes. The mouse Fat-Specific protein 27 (FSP27), a member of the cell death-inducing DFF45-like effector (CIDE) family, is expressed in both BAT and WAT and is associa...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-446
更新日期:2010-07-22 00:00:00
abstract:BACKGROUND:Intragenic tandem repeats occur throughout all domains of life and impart functional and structural variability to diverse translation products. Repeat proteins confer distinctive surface phenotypes to many unicellular organisms, including those with minimal genomes such as the wall-less bacterial monoderms,...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-430
更新日期:2010-07-13 00:00:00
abstract:BACKGROUND:Effective bioinformatics solutions are needed to tackle challenges posed by industrial-scale genome annotation. We present Bcheck, a wrapper tool which predicts RNase P RNA genes by combining the speed of pattern matching and sensitivity of covariance models. The core of Bcheck is a library of subfamily spec...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-432
更新日期:2010-07-13 00:00:00
abstract:BACKGROUND:Rhesus monkeys (Macaca mulatta) are widely-used as experimental animals in biomedical research and are closely related to other laboratory macaques, such as cynomolgus monkeys (Macaca fascicularis), and to humans, sharing a last common ancestor from about 25 million years ago. Although rhesus monkeys have be...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-427
更新日期:2010-07-12 00:00:00
abstract:BACKGROUND:Simple sequence repeats (SSRs) are tandemly repeated sequence motifs common in genomic nucleotide sequence that often harbor significant variation in repeat number. Frequently used as molecular markers, SSRs are increasingly identified via in silico approaches. Two common classes of genomic resources that ca...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-428
更新日期:2010-07-12 00:00:00
abstract:BACKGROUND:About 10% of cases of male infertility are due to the presence of microdeletions within the long arm of the Y chromosome (Yq). Despite the large literature covering this critical issue, very little is known about the pathogenic mechanism leading to spermatogenesis disruption in patients carrying these microd...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-401
更新日期:2010-06-24 00:00:00
abstract:BACKGROUND:The genomewide evaluation of genetic epistasis is a computationally demanding task, and a current challenge in Genetics. HFCC (Hypothesis-Free Clinical Cloning) is one of the methods that have been suggested for genomewide epistasis analysis. In order to perform an exhaustive search of epistasis, HFCC has im...
journal_title:BMC genomics
pub_type: 评论,杂志文章
doi:10.1186/1471-2164-11-403
更新日期:2010-06-24 00:00:00
abstract:BACKGROUND:Digital gene expression profiling was used to characterize the assembly of genes expressed in equine skeletal muscle and to identify the subset of genes that were differentially expressed following a ten-month period of exercise training. The study cohort comprised seven Thoroughbred racehorses from a single...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-398
更新日期:2010-06-23 00:00:00
abstract:BACKGROUND:Two fifths of the world's population is at risk from dengue. The absence of effective drugs and vaccines leaves vector control as the primary intervention tool. Understanding dengue virus (DENV) host interactions is essential for the development of novel control strategies. The availability of genome sequenc...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-380
更新日期:2010-06-16 00:00:00
abstract:BACKGROUND:The ubiquitin-conjugating enzyme HR6B is required for spermatogenesis in mouse. Loss of HR6B results in aberrant histone modification patterns on the trancriptionally silenced X and Y chromosomes (XY body) and on centromeric chromatin in meiotic prophase. We studied the relationship between these chromatin m...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-367
更新日期:2010-06-10 00:00:00
abstract:BACKGROUND:Species of the family Vibrionaceae are ubiquitous in marine environments. Several of these species are important pathogens of humans and marine species. Evidence indicates that genetic exchange plays an important role in the emergence of new pathogenic strains within this family. Data from the sequenced geno...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-369
更新日期:2010-06-10 00:00:00
abstract:BACKGROUND:Spinal cord injury leads to neurological dysfunctions affecting the motor, sensory as well as the autonomic systems. Increased excitability of motor neurons has been implicated in injury-induced spasticity, where the reappearance of self-sustained plateau potentials in the absence of modulatory inputs from t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-365
更新日期:2010-06-09 00:00:00
abstract:BACKGROUND:Sequencing of the approximately 1.7 billion bases of the zebrafish genome is currently underway. To date, few high resolution genetic maps exist for the zebrafish genome, based mainly on single nucleotide polymorphisms (SNPs) and short microsatellite repeats. The desire to construct a higher resolution genet...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-347
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Linkage disequilibrium (LD) plays a fundamental role in population genetics and in the current surge of studies to screen for subtle genetic variants affecting complex traits. Methods widely implemented in LD analyses require samples to be randomly collected, which, however, are usually ignored and thus rais...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-328
更新日期:2010-05-26 00:00:00
abstract:BACKGROUND:The neonatal bovine mammary fat pad (MFP) surrounding the mammary parenchyma (PAR) is thought to exert proliferative effects on the PAR through secretion of local modulators of growth induced by systemic hormones. We used bioinformatics to characterize transcriptomics differences between PAR and MFP from app...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-331
更新日期:2010-05-26 00:00:00
abstract:BACKGROUND:Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. RESULTS:In this study we have sampled over 800 unrelated individuals from the population of Spain,...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-326
更新日期:2010-05-25 00:00:00
abstract:BACKGROUND:One of the key characters of social insects is the division of labor, in which different tasks are allocated to various castes. In termites, one of the representative groups of social insects, morphological differences as well as behavioral differences can be recognized among castes. However, very little is ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-314
更新日期:2010-05-20 00:00:00
abstract:BACKGROUND:Understanding the genome sequence-specific positioning of nucleosomes is essential to understand various cellular processes, such as transcriptional regulation and replication. As a typical example, the 10-bp periodicity of AA/TT and GC dinucleotides has been reported in several species, but it is still uncl...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-309
更新日期:2010-05-17 00:00:00
abstract:BACKGROUND:Designing sustainable animal production systems that better balance productivity and resistance to disease is a major concern. In order to address questions related to immunity and resistance to disease in pig, it is necessary to increase knowledge on its immune system and to produce efficient tools dedicate...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-292
更新日期:2010-05-11 00:00:00
abstract:BACKGROUND:Obesity and phenotypic traits associated with this condition exhibit significant heritability in natural populations of most organisms. While a number of genes and genetic pathways have been implicated to play a role in obesity associated traits, the genetic architecture that underlies the natural variation ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-297
更新日期:2010-05-11 00:00:00
abstract:BACKGROUND:CCCH type zinc finger proteins are RNA binding proteins with regulatory functions at all stages of mRNA metabolism. The best-characterized member, tritetraproline (TTP), binds to AU rich elements in 3' UTRs of unstable mRNAs, mediating their degradation. In kinetoplastids, CCCH type zinc finger proteins have...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-283
更新日期:2010-05-05 00:00:00
abstract:BACKGROUND:The disease caused by Haemonchus contortus, a blood-feeding nematode of small ruminants, is of major economic importance worldwide. The infective third-stage larva (L3) of this gastric nematode is enclosed in a cuticle (sheath) and, once ingested with herbage by the host, undergoes an exsheathment process th...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-266
更新日期:2010-04-27 00:00:00
abstract:BACKGROUND:Sugarcane (Saccharum spp.) has become an increasingly important crop for its leading role in biofuel production. The high sugar content species S. officinarum is an octoploid without known diploid or tetraploid progenitors. Commercial sugarcane cultivars are hybrids between S. officinarum and wild species S....
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-261
更新日期:2010-04-23 00:00:00
abstract:BACKGROUND:Pseudogenes are ubiquitous genetic elements that derive from functional genes after mutational inactivation. Characterization of pseudogenes is important to understand genome dynamics and evolution, and its significance increases when several genomes of related organisms can be compared. Among yeasts, only t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-260
更新日期:2010-04-22 00:00:00